The offspring of an individual with autosomal recessive aHUS are obligate heterozygotes for a pathogenic variant and will usually be asymptomatic. Renal transplantation may be an option, although recurrence of disease in the graft limits its usefulness. Twice-daily exchange of one plasma volume is probably the treatment of choice for those with refractory disease in order to minimize the recycling of infused plasma. In these individuals, extensive plasma exchange was given prior to surgery to provide enough normal CFH to prevent damage to the liver graft. Yachting Vol.
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