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Tsuyoshi Hosoya. Click here to sign up. If the decline is too rapid and the brain is not able to eliminate idiogenic osmoles at the same rate as the decline in serum osmolarity, then the chances of fluid moving into the brain cell and causing swelling are higher. Insulinoterapia Alonso Custodio. The hyperglycemic state creates an osmotic gradient, drawing water from the intracellular space into the extracellular space.
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